https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:3172 Wed 24 Jul 2013 22:22:37 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7827 Sat 24 Mar 2018 08:37:39 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:968 Sat 24 Mar 2018 08:29:56 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29021 A/B human myometrial cell line, abundance of pSer345-PRA was induced by progesterone in a dose-(EC₅₀ ~1 nM) and time-dependent manner. Prevention of pSer345 (by site-directed mutagenesis) abolished the capacity for PR-A to inhibit anti-inflammatory actions of progesterone mediated by PR-B but had no effect on the transrepressive activity of PR-A at a canonical progesterone response element. Taken together, the data show that human parturition involves the phosphorylation of PR-A at serine-345 in myometrial cells and that this process is ligand dependent and induced by a proinflammatory stimulus. We also found that in myometrial cells, pSer345 activates the capacity for PR-A to inhibit antiinflammatory actions of progesterone mediated by PR-B. Phosphorylation of PR-A at serine-345 may be an important functional link between tissue-level inflammation and PR-A-mediated functional progesterone withdrawal to trigger parturition.]]> Sat 24 Mar 2018 07:31:08 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32020 Mon 23 Sep 2019 12:12:16 AEST ]]>